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Publications 

Selected Publications

 

  1. Yoder, A., D. Yu, L. Dong, S. R. Iyer, X. Xu, J. Kelly, J. Liu, W. Wang, P. J. Vorster, L. Agulto, D. A. Stephany, J. N. Cooper, J. W. Marsh and Y. Wu. 2008. HIV-1 envelope-CXCR4 interaction activates cofilin to overcome cortical actin restriction in resting CD4 T cells. Cell 134:782-792.      

  2. He, S., Y. Fu, J. Guo, M. Spear, J. Yang, B. Trinité, C. Qin, S. Fu, Y. Jiang, Z. Zhang, J. Xu, H. Ding, D. N. Levy, W. Chen, E. Petricoin III, L. A. Liotta, H. Shang, Y. Wu. 2019, Cofilin hyperactivation in HIV infection and targeting the cofilin pathway using an anti-α4β7 integrin antibody. Science Advances 5(1), eaat7911. DOI: 10.1126/sciadv.aat7 91                                                                                                               

  3. Wu, Y. and J. W. Marsh. 2001. Selective transcription and modulation of resting T cell activity by preintegrated HIV DNA. Science 293(5534):1503-150                                                                                                                                                                           

  4. Liu, Y., Y. Fu, Q. Wang, M. Li, Z. Zhou, D. Dabbagh, C. Fu, H, Zhang, S. Li, T. Zhang, J. Gong, X. Kong, W. Zhai, J. Su, J. Sun, Y. Zhang, X. Yu, Z. Shao, F. Zhou*, Y. Wu* & X. Tan*. 2019, Proteomic profiling of HIV-1 infection of human CD4 T cells identifies PSGL-1 as an HIV restriction factor. Nature Microbiology, 4:8132, DOI:10.1038/s41564-019-0372-2                                                                                        

  5. Fu, Y., S. He, A. A. Waheed, D. Dabbagh, Z. Zhou, B. Trinité, Z. Wang, J. Yu, D. Wang, F. Li, D. N. Levy, H. Shang, E. O. Freed, and Y. Wu. 2020, PSGL-1 restricts HIV-1 infectivity by blocking virus particle attachment to target cells. PNAS (in print)                                                 

  6. Wu, Y. 2014. Cofilin/Traficking. In: Encyclopedia of AIDS. Thomas J. Hope, Mario Stevenson, and Douglas Richman, eds. Springer. DOI 10.1007/978-1-4614-9610-6_69-1                                                                                                                                                        

  7. Spear, M., J. Guo, and Y. Wu. 2013. Novel anti-HIV therapeutics targeting chemokine receptors and actin regulator pathways (Invited review). Immunological Review 256(1):300-312.                                                                                                                                                  

  8. Wang, Z., Z. Tang, Y. Zheng, D. Yu, M. Spear, S. R. Iyer, B. Bishop, and Y. Wu. 2010. Development of a Non-integrating Rev-dependent Lentiviral Vector Carrying Diphtheria Toxin A Chain and Human TRAF6 to Target HIV Reservoirs. Gene Therapy DOI:10.1038/gt.2010.53.

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Peer-Reviewed Publications

 

 

He, S., Y. Fu, J. Guo, M. Spear, J. Yang, B. Trinité, C. Qin, S. Fu, Y. Jiang, Z. Zhang, J. Xu, H. Ding, D. N. Levy, W. Chen, E. Petricoin III, L. A. Liotta, H. Shang, Y. Wu. 2019, Cofilin hyperactivation in HIV infection and targeting the cofilin pathway using an anti-a4b7 integrin antibody . Science Advances 5(1), eaat7911. DOI: 10.1126/sciadv.aat7911

 

Perez, S., A. Johnson, S. Xiang, J. Li, B. T. Foley, L. Doyle-Meyers, A. Panganiban, A. Kaur, R. S. Veazey, 2018, Y. Wu, and B. Liang. Persistence of

SIV in the brain of SIV-infected Chinese rhesus macaques with or without antiretroviral therapy. J. Neurovirology, 24(1): 62-74

 

Wang, R., Zhang, X., H. Ding, Y. Qiao, X. Han, W. Geng, G. Guan, H. Cui, B. Zhao, Y. Wu, G. Liang and H. Shang. 2018. AID recruits the RNA exosome to degrade HIV-1 nascent transcripts through interaction with the Tat-PTEFb-TAR RNP complex. FEBS Letters, 592:284-293.

 

Meltzer, B., D. Dabbagh, J. Guo, F. Kashanchi, M. Tyagi, Y. Wu. 2018. Tat controls transcriptional persistence of unintegrated HIV genome in primary human macrophages. Virology, 518:241-252.

 

Yi, F., J. Guo, D. Dabbagh, M. Spear, S. He, K. Kehn-Hall, J. Fontenot, Y. Yin, M. Bibian, C. M. Park, K.  Zheng, H. Park, V. Soloveva, D. Gharaibeh, C. Retterer, R. Zamani, M. L. Pitt, J. Naughton, Y. Jiang, H. Shang, R. M. Hakami, B. Ling, J. A. T. Young, S. Bavari, X. Xu, Y. Feng, and Y. Wu. 2017. Discovery of Novel Small Molecule Inhibitors of LIM Domain Kinase for Inhibiting HIV-1. J. Virol. doi: 10.1128/JVI.02418-16

 

 

Wang, Z., T. Wu, M. Ma, Z. Zhang, Y. Fu, J. Liu, J. Xu, H. Ding, X. Han, Z. Chu, Y. Wu, H. Shang, and Y. Jiang. 2017. Elevated IP-10 and its receptor CXCR3 impairs NK cell function during HIV infection. J. Leukocyte Biology.

 

 

Li, Q., W. Li, W. Yin, J. Guo, Z. Zhang, D. Zeng, X. Zhang; Y. Wu*, X. Zhang*, and Z. Cui*. 2017. Single-Particle Tracking of Human Immunodeficiency Virus Type 1 Productive Entry into Human Primary Macrophages. ACS Nano. DOI: 10.1021/acsnano.7b00275 (*Co-corresponding author)

 

 

Guo, J., and Wu, Y. 2015. Genistein as an antioxidant and use in treating HIV infection. In: HIV/AIDS: Oxidative Stress and Dietary Antioxidants. Victor R. Preedy and Ronald R. Watson, eds. Elsevier.

 

 

Ma Y, He Z, Tan T, Li W, Zhang Z, Song S, Zhang X, Hu Q, Zhou P, Wu Y, Zhang XE, Cui Z. 2016. Effects Real-Time Imaging of Single HIV-1 Disassembly with Multicolor Viral Particles. ACS Nano 10(6):6273-82. DOI: 10.1021/acsnano.6b02462.

 

 

Liang H., Toro R, Wu Y, Guo J. 2015. Effects of Tadalafil and Sildenafil on HIV Infection in vitro. J Hum Virol Retrovirol 2(1): 00030. DOI: 10.15406/jhvrv.2015.02.00030

 

 

Wu, Y. 2015. Flow Cytometry-based quantification of HIV-induced T cell chemotactic response. In: Methods in Molecular Biology: Chemotaxis (2nd). Tian Jin and Dale Hereld, eds. Humana Press Inc.

 

 

Guendel I., B. W. Meltzer, A. Baer, S. Dever, K. Valerie, J. Guo, Y. Wu, K. Kehn-Hall. 2015. BRCA1 functions as a novel transcriptional cofactor in HIV-1 infection. Virology Journal 12:40. 2014

 

 

Wu, Y. 2014. Actin. In: Encyclopedia of AIDS. Thomas J. Hope, Mario Stevenson, and Douglas Richman, eds. Springer. DOI 10.1007/978-1-4614-9610-6_71-1.

 

 

Wu, Y. 2014. Cofilin/Traficking. In: Encyclopedia of AIDS. Thomas J. Hope, Mario Stevenson, and Douglas Richman, eds. Springer. DOI 10.1007/978-1-4614-9610-6_69-1.

 

 

Spear M. and Wu, Y. 2014. Arp2/3. In: Encyclopedia of AIDS. Thomas J. Hope, Mario Stevenson, and Douglas Richman, eds. Springer. 2014. DOI 10.1007/978-1-4614-9610-6_71-1.

 

 

Xu, G. J. Guo, and Y. Wu. 2014. Chemokine receptor CCR5 antagonist maraviroc: medicinal chemistry and clinical applications. Current Topics in Medicinal Chemistry 14:1504-14.

 

 

Spear M, and Y. Wu. 2014. Viral exploration of actin: force-generation and scaffolding functions in viral infection. Virologica Sinica 29(3):139-147

 

 

Spear M, J. Guo, A. Turner, D. Yu, W. Wang, Xi. Hu, J. Kuhn, Y. Wu. 2014. HIV-1 triggers WAVE2 serine 351 phosphorylation in primary CD4 T cells and macrophages, mediating Arp2/3-dependent nuclear migration. J. Bio. Chem. 289, 6949-6959

 

 

Spear, M., J. Guo, and Y. Wu. 2013. Novel anti-HIV therapeutics targeting chemokine receptors and actin regulatory pathways (Invited review). Immunological Reviews 256, 300-312

 

 

Hawley, T. M. Spear, J. Guo, and Y. Wu. 2013. Inhibition of HIV replication in vitro by clinical immunosuppressants and chemotherapeutic agents. Cell & Biosciences 3:22

 

 

Guo, J., X. Xu, T. Rasheed, D. Yu, H. Liang, F. Yi, T. Hawley, T. Jin, B. Ling, and Y. Wu. 2013. Genistein interferes with SDF-1 and HIV-mediated actin dynamics and inhibits HIV infection of resting CD4 T cells. Retrovirology 10:62

 

 

Li, Z., J. Guo, Y. Wu, and Q. Zhou. 2012. The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation. Nucl. Acids Res. 41, 277-287

 

 

Guo, J., X. Xu, W. Yuan, T. Jin, Y. Wu. 2012. HIV gp120 is an aberrant chemoattractant for blood resting CD4 T cells. Current HIV Research 19, 636-642

 

 

Wu, Y., and M. Spear. 2012. Actin, Arp2/3, and Cofilin/trafficking. Encyclopedia of AIDS edited by Thomas. Hope, Douglas. D. Richman, and Mario Stevenson. Springer (In print)

 

 

Wang, W., J. Guo, D. Yu, P. J. Vorster, W. Chen, and Y. Wu. 2012. A dichotomy in cortical actin and chemotactic actin activity between human memory and naive T cells contributes to their differential susceptibility to HIV-1 infection. J. Bio. Chem. 287, 35455-35469

 

 

Spear, M. J. Guo, and Y. Wu. 2012. The trinity of the cortical actin in the initiation of HIV-1 infection. Retrovirology 9:45

 

 

Xu, X., J. Guo, P. Vorster, and Y. Wu. 2012. Involvement of LIM Kinase 1 in actin polarization in human CD4 T cells. Involvement of LIM Kinase 1 in actin polarization in human CD4 T cells. Communicative & Integrative Biology 5, 381-383

 

 

Guo, J., W. Wang, D. Yu, Y. Wu. 2011. Spinoculation triggers dynamic actin and cofilin activity facilitating HIV infection of transformed and resting CD4 T cells. J. Virol. 85, 9824-33

 

 

Vorster, J. P., J. Guo,  A. Yoder, W. Wang, Y. Zheng, X. Xu, D. Yu, Spear, M, Y. Wu. 2011. LIM Kinase 1 Modulates Cortical Actin and CXCR4 Cycling and is Activated by HIV-1 to Initiate Viral Infection. J. Bio. Chem.  286, 12554-12564

 

 

Yoder, A., D. Yu, Z. Cai, X. Zhang, J. Guo, and Y. Wu. 2011. Effect of microtubule modulators on HIV-1 infection of transformed and resting CD4 T cells. J. Virol. 85, 3020-3024

 

 

Maruyama, T., J. Li, J. P. Vaque, J. E. Konkel, W. Wang, B. Zhang, P. Zhang, B. F. Zamarron, D. Yu, Y. Wu, Y. Zhuang, J. S. Gutkind & W. Chen. 2010. Control of the Differentiation of Regulatory T Cells and TH17 Cells by the DNA-binding Inhibitor Id3. Nature Immunology 12, 86-95

 

Guo J., C. Enos, Y. Wu. 2010. Specific Marking of HIV-1 Positive Cells using a Rev-dependent Lentiviral Vector Expressing the Green Fluorescent Protein. J. Vis. Exp. 43, 2198

 

 

Wu, Y. 2010. Chemokine Control of HIV Infection: Beyond a Binding Competition. Retrovirology 7:86

 

 

Wang, Z., Z. Tang, Y. Zheng, D. Yu, M. Spear, S. R. Iyer, B. Bishop, and Y. Wu. 2010. Development of a Non-integrating Rev-dependent Lentiviral Vector Carrying Diphtheria Toxin A Chain and Human TRAF6 to Target HIV Reservoirs. Gene Therapy 17, 1063-1076

 

 

Wu, Y and A. Yoder. 2009. Chemokine Coreceptor Signaling in HIV-1 Infection and Pathogenesis. PLoS Pathogens 5(12): e1000520

 

 

Yu, D., W. Wang, A. Yoder, M. Spear and Y. Wu. 2009. The HIV Envelop but not VSV-G Glycoprotein is Capable of Mediating HIV Latent Infection of Resting CD4 T Cells. PLoS Pathogens 5(10): e100633

 

 

Iyer, S., D. Yu, A. Biancotto, L. B. Margolis, Y. Wu. 2009. Measurement of HIV-1 Preintegration Transcription Using the Rev-dependent Rev-CEM Cell Reveals a Sizable Transcribing DNA Population Comparable with that of Proviral Templates. J. Virol. 83, 8662-8673

 

 

Wu, Y. 2009. The Co-receptor Signaling Model of HIV-1 Pathogenesis in Peripheral CD4 T cells. Retrovirology 6:41 (highly accessed).

 

 

Wu, Y. 2009. Chemokine Receptor Signaling and HIV Infection (book chapter), Methods in Molecular Biology: Chemotaxis The humana Press Inc.

 

 

Wu, Y., A. Yoder, D. Yu, W. Wang, J. Liu, T. Barrett, D. Wheeler, K. Schlauch. 2008. Cofilin activation in peripheral CD4 T cells of HIV-1 infected patients:  a pilot study.Retrovirology 5:95

 

 

Wu, Y. 2008. The second chance story of HIV-1 DNA: Unintegrated? Not a problem! Retrovirology 5:61 (Invited Commentary, highly accessed)

 

 

Yoder, A., D. Yu, L. Dong, S. R. Iyer, X. Xu, J. Kelly, J. Liu, W. Wang, P. J. Vorster, L. Agulto, D. A. Stephany, J. N. Cooper,  J. W. Marsh and Y. Wu. 2008. HIV-1 envelope-CXCR4 interaction activates cofilin to overcome cortical actin restriction in resting CD4 T cells. Cell 134, 782-792

 

 

Young, J., Z. Tang, Q. Yu, D. Yu, and Y. Wu. 2008. Selective killing of HIV-1-positive macrophages and T cells by a Rev-dependent lentivirus carrying anthrolysin O from Bacillus anthracis. Retrovirology 5:36 (highly accessed)

 

 

Kelly, J., H. Beddall, D. Yu, J. W. Marsh and Y. Wu. 2008. Human Macrophages Support Persistent Transcription From Unintegrated HIV-1 DNA. Virology 372, 300-312

 

 

Amarnath, S., L. Dong, J. Li, Y. Wu and W. Chen. 2007. Endogenous TGF-beta activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1 infected human CD4+CD25- T cells. Retrovirology 4:57

 

 

Wu, Y., M. H. Beddall and J. W. Marsh 2007. Rev-dependent indicator T cell line. Current HIV Research 5, 394-402

 

 

Wu, Y., M. H. Beddall and J. W. Marsh. 2007. Rev-dependent lentiviral expression vector. Retrovirology 4:12 (highly accessed)

 

 

Carstens, E. B and Y. Wu. 2007. No single homologous region is essential for DNA replication of the baculovirus Autographa californica multiple nucleopolyhedrovirus. J. Gen. Virol. 88,114-122

 

 

Wu, Y. 2004. HIV-1 gene expression: lessons from provirus and non-integrated DNA. Retrovirology 1:13 (highly accessed)

 

 

Wu, Y.  and J. Marsh. 2003. Gene transcription in HIV infection. Microbes and Infection 5, 1023-1027

 

 

Wu, Y. and J. W. Marsh. 2003. Early transcription from nonintegrated DNA in human immunodeficiency virus infection. J. Virol. 77, 10376-10382

 

 

Wu, Y. and J. W. Marsh. 2001. Selective transcription and modulation of resting T cell activity by preintegrated HIV DNA. Science 293, 1503-1506

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